HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Butyn-2-ol → 1-(3-Bromo-1,2-oxazol-5-yl)ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Butyn-2-ol | HCID 16239 | — |
| Reactant | 1-bromo-N-hydroxymethanecarbonimidoyl bromide | HCID 2763219 | — |
| Product | 1-(3-Bromo-1,2-oxazol-5-yl)ethan-1-ol | HCID 13802086 | — |
Reaction Steps
Reaction of dibromoformaldoxime with 3-butyn-2-ol gives 3-bromo-5-(1-hydroxyethyl)-isoxazole which is converted by oxidation into 3-bromo-5-acetylisoxazole, an intermediate for the preparation of 1-(3-bromoisoxazol-5-yl)-2-tert.butylamine-ethanol, a compound having broncodilating activity (European Patent No. 16255) known as Broxaterol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04772719 |
| Source dataset | uspto-grants-1988_09 |
| ORD ID | ord-ce8fed9ef9c9486888926d94a4cda4ea |
| Source note | uspto-grants-1988_09 |