2,2,3,3-Tetrafluoro-5-nitrobenzofuran → 5-Benzofuranamine, 2,2,3,3-tetrafluoro-2,3-dihydro-

HRID 622865Notes

Reaction equation

HRID 622865 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([F:13])([F:12])[C:9]([F:15])([F:14])[C:8]=2[CH:16]=1)([O-])=O>CO.[Pt]=O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([F:12])([F:13])[C:9]([F:15])([F:14])[C:8]=2[CH:16]=1

Participants

4

Reactant 1

HCID 137849862,2,3,3-Tetrafluoro-5-nitrobenzofuran

Product 1

HCID 137849875-Benzofuranamine, 2,2,3,3-tetrafluoro-2,3-dihydro-Yield 94.4%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

Hydrogenation of 2.15 g (0.011 mole) of 5-nitro-2,2,3,3-tetrafluorobenzofuran (prepared as in Example 1, Part A) with a catalytic amount (0.25 g) of platinum oxide in 150 ml of methanol produced 2.15 g of 5-amino-2,2,3,3-tetrafluorobenzofuran.

Sources & evidence

ORD record
ord-32e5757f25e848859caed2da37cc669d
Source dataset
uspto-grants-1988_09
Patent number
US04772730

Reaction notes

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