Sulfuryl chloride → HCID 13769781, compound

Participants

Reaction Conditions

Reaction Steps

After dissolving 8.0 g of 3,3,4-trimethyl-4-chloro-2-pentanone in 30 ml of dichloromethane, two drops of dicyclohexylamine were added, and then 10.0 g of sulfuryl chloride was added dropwise at 0° C. After addition, the reaction solution was stirred at 20° C for 24 hours, poured into ice water and extracted with dichloromethane. The dichloromethane layer was washed with water, dried over magnesium sulfate and concentrated. The residue obtained was column-chromatographed on silica gel to obtain 6.1 g of 1,4-dichloro-3,3,4-trimethyl-2-pentanone (a compound of the foregoing formula (II) wherein a substituent X is a chlorine atom) as a pale yellow oil.

Provenance & Evidence