Water → 2,2,3,3-Tetramethylcyclopropanecarboxylic acid
Reaction equation
Br[CH2:2][C:3](=O)[C:4]([CH3:10])([CH3:9])[C:5](Cl)([CH3:7])[CH3:6].[OH-:12].[K+].[OH2:14]>O1CCOCC1>[CH3:9][C:4]1([CH3:10])[C:5]([CH3:7])([CH3:6])[CH:3]1[C:2]([OH:14])=[O:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
A solution of 4.1 g of 1-bromo-4-chloro-3,3,4-trimethyl-2-pentanone in 10 ml of 1,4-dioxane was added dropwise at 30° C to a solution comprising 3.3 g of potassium hydroxide, 30 ml of water and 20 ml of dioxane, and the resulting solution was stirred at 20° C for 15 hours. Thereafter, the reaction solution was worked up in the same manner as in Example 1 to obtain 1.8 g of the desired 2,2,3,3-tetramethylcyclopropane-1-carboxylic acid as a white crystal (yield, 76%).
Workup
- customto obtain
Sources & evidence
- ORD record
- ord-5109dd18055c4274973303241ad2c2c4
- Source dataset
- uspto-grants-1988_09
- Patent number
- US04772753
Reaction notes
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