反应详情

A mixture of 4-hydroxy-4-(phenylethynyl)-5-[2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethyl]-2-cyclohexene-1-one (4 g, 0.011 mole), the title product of Example 1c, pyridinium chloride (2.5 g, 0.022 mole) and absolute methanol (30 mL) were combined and heated to reflux for 4 hr. The reaction mixture was quenched into 50 mL of water, ether was added, the resulting layers separated, the aqueous layer extracted with ether, the ether extracts combined, washed with water, brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give 3.0 g of the title product.

1. temperatureheated
2. temperatureto reflux for 4 hr
3. customThe reaction mixture was quenched into 50 mL of water, ether
4. additionwas added
5. customthe resulting layers separated
6. extractionthe aqueous layer extracted with ether
7. washwashed with water, brine
8. dry with materialdried over anhydrous Na2SO4
9. filtrationfiltered
10. concentrationconcentrated in vacuo