反应详情

1.5 ml of o-fluoro-nitrobenzene and 8.2 g of L-proline were stirred at 60° C. for 3 hours in 50 ml DMSO. The mixture was then evaporated in vacuo to give a yellow oil. This oil was dissolved in 250 ml 96% ethanol and was hydrogenated at normal pressure at room temperature using 2 g 5% Pd/C as catalyst. After completion of hydrogen uptake, the mixture was filtered and evaporated in vacuo to give the title compound. M.p. 169°-172° C.

1. customThe mixture was then evaporated in vacuo
2. customto give a yellow oil
3. customwas hydrogenated at normal pressure at room temperature
4. filtrationAfter completion of hydrogen uptake, the mixture was filtered
5. customevaporated in vacuo