Thionyl Chloride → HCID 13752890, compound

Participants

Reaction Steps

Thionylchloride (7.7 g) was added to 2-methylthiopyridine-5-methanol (7.8 g) (from the above referential example 1c) in chloroform (30 ml) at room temperature. After stirring for some time, the volatile matter was distilled off under reduced pressure to give 2-methylthio-5-chloromethyl pyridine hydrochloride (10.4 g) stoichiometrically (m.p. 127°~130° C.) ##STR28## The compounds synthesized the same way as in the above referential examples 1a, 1b, 1c are exemplified below. Method of referential example 1a: ##STR29## Method of referential example 1b: ##STR30## Method of referential example 1c: ##STR31##

Provenance & Evidence