Diethyl Ether → HCID 10537075, compound

Participants

Reaction Steps

5.05 g (5 mmol) of triethylamine in 20 ml of diethyl ether were added dropwise at -10° C. to a solution of 3.86 g (5.5 mmol) of 3-butyn-1-ol and 9.50 g (5 mmol) of 4-chlorobenzene N-hydroxycarboximidoyl chloride in 200 ml of dry diethyl ether. After 3 hours the reaction mixture was filtered, the filtrate was evaporated and the residue was recrystallized from ethyl acetate/hexane to yield 6.15 g (55%) of 3-(4-chlorophenyl)-5-isoxazolyl-2-ethanol of melting point 65.5°-67.5° C. after crystallization from ethyl acetate.

Provenance & Evidence