Diethyl Ether → HCID 21290717, compound

Participants

Reaction Steps

2.02 g (0.02 mol) of triethylamine in 20 ml of diethyl ether were added dropwise over a period of 15 minutes at -10° C. to a solution of 4.49 g (0.02 mol) of 3,4-dichlorobenzene N-hydroxycarboximidoyl chloride in 90 ml of dry diethyl ether. After 0.5 hour at -5° C. to -10° C. 4.004 g (0.022 mol) of methyl 2-propynyloxy-2-methylpropionate were added and the mixture was stored at -5° C. for 48 hours. The mixture was filtered, the filtrate was evaporated and the residue was chromatographed on 150 g of silica gel using hexane/ethyl acetate (4:1) for the elution. There were obtained 6 g (87%) of pure methyl 2-[[3-(3,4-dichlorophenyl)-5-isoxazolyl]methoxy]-2-methylpropionate in the form of an oil.

Provenance & Evidence