反应详情

In a 50-ml four-necked flask equipped with a thermometer, reflux condenser and stirrer, were charged 2.30 g (0.010 mole) of 5-methylthio-2,4,6-trichloropyrimidine and 15 ml of formic acid. While stirring the contents at room temperature, 1.07 g (0.011 mole) of potassium thiocyanate was added. Then, the resulting mixture was heated and was then stirred at 50° C. for 1 hour. After cooling the reaction mixture, it was poured into a great deal of water. The precipitated solid was collected by filtration and dried to obtain 2.34 g of crude crystals (yield: 92.9%). A portion of the crude crystals was recrystallized from ethyl acetate, thereby obtaining a purified product. m.p. 143°-144.5° C.

1. customIn a 50-ml four-necked flask equipped with a thermometer
2. temperaturereflux condenser and stirrer
3. temperatureThen, the resulting mixture was heated
4. stirringwas then stirred at 50° C. for 1 hour
5. temperatureAfter cooling the reaction mixture, it
6. filtrationThe precipitated solid was collected by filtration
7. customdried