Ammonia → HCID 178425968, compound

Participants

Reaction Steps

Boc-Arg(Mts)-OH prepared from 1.3 kg of Boc-Arg(Mts)-OH·CHA are dissolved at ambient temperature in 6.2 kg of THF, and 280 g of NMM are added. To this solution 380 g of SBCF are added at -10° C., and stirring is continued at -10° C. for 15 minutes, and then 0.69 kg of 29% aqueous ammonia are added at -10° C. The medium is stirred at -10° C. for 30 mins. and then at 5° C., and the development of the reaction is followed by HPLC. The reaction is terminated after 30 mins. The medium is poured into 31.5 kg of water, and then 19.2 kg of AcOEt are added. After stirring for 15 mins, the organic phase is washed by:

Provenance & Evidence