HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Boc-Ser(Bzl)-Tyr(Bzl)-OBzl | HCID 14012223 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Product | N2-((tert-Butoxy)carbonyl)-L-asparagine | HCID 82035 | — |
Reaction Steps
[α]D20 =-16.7° (C=1, DMF) (B) From 133.2 g of DP-2, 100 g of methansulfonic acid, 84.4 g of Et3N, 36.7 g of HOBt.H2O, 55.7 g of Boc-Asn-OH and 37.2 g of WSC, 157 g (100%) of DP-3 are obtained by employing the same technique described in example I-7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04774319 |
| Source dataset | uspto-grants-1988_09 |
| ORD ID | ord-3cec2931050a4df88a6f2bd44591a367 |
| Source note | uspto-grants-1988_09 |