HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623349Generated: October 29, 2026
Methanesulfonic Acid → (S)-Methyl piperidine-3-carboxylate
https://huagongshe.com/reaction/623349
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | (3S)-1-((tert-butoxy)carbonyl)piperidine-3-carboxylic acid | HCID 6951168 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-Methyl piperidine-3-carboxylate | HCID 18727136 | — |
Reaction Steps
Methanesulfonic acid (576 mg, 6 mmol) was added to a solution of (S)—N-(tert-butoxycarbonyl)nipecotic acid (1145 mg, 5 mmol) and methanol (5 mL). When the mixture was stirred at 25° C. for 16 hours, (S)-methyl nipecotate was produced, and the object (S)-nipecotic acid was not produced.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09302980B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-eec1b9c0cf7f4088aed943b49beea7bb |
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| Source note | uspto-grants-2016_04 |
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