HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Morpholino-1-propanol → Methyl 3-morpholin-4-ylpropyl (2E)but-2-ene-1,4-dioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Morpholino-1-propanol | HCID 199576 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | (E)-4-methoxy-4-oxobut-2-enoate | HCID 21721168 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 3-morpholin-4-ylpropyl (2E)but-2-ene-1,4-dioate | HCID 71711669 | — |
Reaction Steps
Monomethyl fumarate (MMF) was reacted with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDAC) (1.2 eq) in dichloromethane (DCM) at ca. 0° C. 3-Morpholin-4-yl-propan-1-ol (1 eq) and 4-N,N-dimethylaminopyridine (DMAP) (catalytic amount) were added to the activated carboxylic acid. After the completion of the reaction, followed by the work-up of the reaction mixture, the title compound was isolated as a viscous-oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302977B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-23bb60e66f7149aabb84ae4d79433115 |
| Source note | uspto-grants-2016_04 |