反应详情

A suspension of cis-4-aminocyclohexanecarboxylic acid (5.0 g, 34.9 mmol) in methanol (50 mL) was stirred at room temperature and SOCl2 (7.1 mL, 98.4 mmol) was added dropwise over 20 minutes, causing the solid to dissolve. The solution was stirred overnight and the methanol was then removed under reduced pressure. The residual solid was triturated with diethyl ether and air-dried and the title compound obtained as an off-white powder (6.0 g).

1. dissolutionto dissolve
2. stirringThe solution was stirred overnight
3. customthe methanol was then removed under reduced pressure
4. customThe residual solid was triturated with diethyl ether
5. customair-dried