tert-Butylsulfinamide, (R)-(+)- → (R)-2-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propyl)propane-2-sulfinamide

Participants

Role	Name	HCID	Charge
Reactant	tert-Butylsulfinamide, (R)-(+)-	HCID 10964479	—
Reactant	1-(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)propan-1-one	HCID 67509769	—
Product	(R)-2-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propyl)propane-2-sulfinamide	HCID 67509323	50%

Reaction Steps

The title compound is prepared in 50% yield (0.39 g, colorless oil) from 1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propan-1-one (0.54 g, 2.29 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09302991B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-bab99f2e665a4372b36b7bcfaba8312b
Source note	uspto-grants-2016_04