tert-Butylsulfinamide, (R)-(+)- → HCID 67509300, compound

HRID 623438Notes

Reaction equation

HRID 623438 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11](=O)[CH3:12])[CH:6]=1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[CH3:16][C:17]([S@:20]([NH:22][CH:11]([C:7]1[CH:6]=[C:5]([O:4][CH2:3][C:2]([F:15])([F:14])[F:1])[CH:10]=[CH:9][N:8]=1)[CH3:12])=[O:21])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 67509987HCID 67509987, compound

Product 1

HCID 67509300HCID 67509300, compoundYield 35%

Procedure

The title compound is prepared in 35% yield (60 mg, colorless oil) from 1-(4-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethanone (120 mg, 0.53 mmol, Step-3) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-2941029a05f14f9db09d435c31154c04
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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