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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623440Generated: October 27, 2026

1-(4-(Trifluoromethoxy)phenyl)ethan-1-one → (R)-2-methyl-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)propane-2-sulfinamide

https://huagongshe.com/reaction/623440

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-(Trifluoromethoxy)phenyl)ethan-1-oneHCID 522821—
Reactanttert-Butylsulfinamide, (R)-(+)-HCID 10964479—
Product(R)-2-methyl-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)propane-2-sulfinamideHCID 6750961377%

Reaction Steps

The title compound is prepared in 77% yield (0.35 g, colorless oil) from 1-(4-(trifluoromethoxy)phenyl)ethanone (0.30 g, 1.47 mmol) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302991B2
Source datasetuspto-grants-2016_04
ORD IDord-4dfe32c8bd9344bdb2fe1c594a0f5649
Source noteuspto-grants-2016_04