tert-Butylsulfinamide, (R)-(+)- → HCID 67509685, compound

HRID 623441Notes

Reaction equation

HRID 623441 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[CH:10]=[C:9]([C:11](=O)[CH3:12])[CH:8]=[CH:7][N:6]=1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[CH3:16][C:17]([S@:20]([NH:22][CH:11]([C:9]1[CH:8]=[CH:7][N:6]=[C:5]([O:4][CH2:3][C:2]([F:15])([F:14])[F:1])[CH:10]=1)[CH3:12])=[O:21])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 67508725HCID 67508725, compound

Product 1

HCID 67509685HCID 67509685, compoundYield 75%

Procedure

The title compound is prepared in 75% yield (0.52 g, a white solid) from 1-(2-(2,2,2-trifluoroethoxy)pyridin-4-yl)ethanone (0.47 g, 2.14 mmol, Step-3) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-42da5dfb35bc4df48eab991bd6d5dbf8
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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