tert-Butylsulfinamide, (R)-(+)- → HCID 67511411, compound

HRID 623446Notes

Reaction equation

HRID 623446 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH3:9])[CH:5]=[C:4]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])[N:3]=1.[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[CH3:17][C:18]([S@:21]([NH:23][CH:8]([C:6]1[CH:5]=[C:4]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])[N:3]=[C:2]([CH3:1])[CH:7]=1)[CH3:9])=[O:22])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 67509189HCID 67509189, compound

Product 1

HCID 67511411HCID 67511411, compoundYield 78%

Procedure

The title compound is prepared in 78% yield (50 mg, colorless oil) from 1-(2-methyl-6-(2,2,2-trifluoroethoxy)pyridin-4-yl)ethanone (44 mg, 0.19 mmol, Step-3) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-d29e0f59dcd34ddb85da2eba52f62161
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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