tert-Butylsulfinamide, (R)-(+)- → HCID 67508633, compound

HRID 623451Notes

Reaction equation

HRID 623451 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:11](=O)[CH3:12])[CH:8]=[CH:9][CH:10]=1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[CH3:16][C:17]([S@:20]([NH:22][CH:11]([C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([O:4][CH2:3][C:2]([F:15])([F:14])[F:1])[CH:6]=1)[CH3:12])=[O:21])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 24707596HCID 24707596, compound

Product 1

HCID 67508633HCID 67508633, compoundYield 72%

Procedure

The title compound is prepared in 72% yield (0.71 g, colorless oil) from 1-(3-(2,2,2-trifluoroethoxy)phenyl)ethanone (0.67 g, 3.08 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-786e5c707f3c407ebd88d315aeb78cfc
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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