tert-Butylsulfinamide, (R)-(+)- → HCID 67509605, compound

HRID 623453Notes

Reaction equation

HRID 623453 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=O)[CH3:12])=[CH:7][CH:6]=1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[CH3:16][C:17]([S@:20]([NH:22][CH:11]([C:8]1[CH:9]=[CH:10][C:5]([O:4][CH2:3][C:2]([F:15])([F:14])[F:1])=[CH:6][CH:7]=1)[CH3:12])=[O:21])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 126474971-[4-(2,2,2-trifluoroethoxy)phenyl]ethanone

Product 1

HCID 67509605HCID 67509605, compoundYield 76%

Procedure

The title compound is prepared in 76% yield (0.73 g, colorless oil) from 1-(4-(2,2,2-trifluoroethoxy)phenyl)ethanone (0.65 g, 2.99 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-a7484d2195a246639d506af5fb4ee4b8
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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