HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydride → 3-Pyridinemethanol, 5-chloro-6-(2,2,2-trifluoroethoxy)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydride | HCID 166653 | — |
| Reactant | HCID 67509641 | HCID 67509641 | — |
| Product | 3-Pyridinemethanol, 5-chloro-6-(2,2,2-trifluoroethoxy)- | HCID 61256331 | 78% |
Reaction Steps
The title compound is prepared in 78% yield (210 mg, a white solid) from methyl 5-chloro-6-(2,2,2-trifluoroethoxy)nicotinate (300 mg, 1.1 mmol, Step-1) and diisobutylalminium hydride (1.0 M in hexane, 2.4 mL, 2.4 mmol) by the similar manner in Step-3 of Amine-4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-14a2c3c807bd493783a0131c45bfe29f |
| Source note | uspto-grants-2016_04 |