tert-Butylsulfinamide, (R)-(+)- → HCID 67510164, compound

HRID 623455Notes

Reaction equation

HRID 623455 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH3:9])=[CH:4][C:3]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:23][S@@:21]([C:18]([CH3:20])([CH3:19])[CH3:17])=[O:22])[CH3:9])=[CH:4][C:3]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 67510314HCID 67510314, compound

Product 1

HCID 67510164HCID 67510164, compoundYield 83%

Procedure

The title compound is prepared in 83% yield (0.21 g, colorless oil) from 1-(4-fluoro-3-(2,2,2-trifluoroethoxy)phenyl)ethanone (0.18 g, 0.76 mmol, Step-3) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-40fecaf1cb9349678165484540bebe64
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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