tert-Butylsulfinamide, (R)-(+)- → HCID 67509952, compound

HRID 623465Notes

Reaction equation

HRID 623465 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][NH:4][C:5]1[N:10]=[CH:9][C:8]([C:11](=O)[CH3:12])=[CH:7][CH:6]=1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[CH3:16][C:17]([S@:20]([NH:22][CH:11]([C:8]1[CH:9]=[N:10][C:5]([NH:4][CH2:3][C:2]([F:15])([F:14])[F:1])=[CH:6][CH:7]=1)[CH3:12])=[O:21])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 67509283HCID 67509283, compound

Product 1

HCID 67509952HCID 67509952, compoundYield 28%

Procedure

The title compound is prepared in 28% yield (180 mg, colorless oil) from 1-(6-((2,2,2-trifluoroethyl)amino)pyridin-3-yl)ethanone (441 mg, 2.02 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-a49b13fb351f4c05b45a5e19485d7c87
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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