tert-Butylsulfinamide, (R)-(+)- → HCID 67511066, compound

HRID 623472Notes

Reaction equation

HRID 623472 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][O:4][CH2:5][CH2:6][O:7][C:8]1[N:13]=[CH:12][C:11]([C:14](=O)[CH3:15])=[CH:10][CH:9]=1.[CH3:19][C:20]([S@:23]([NH2:25])=[O:24])([CH3:22])[CH3:21]>>[CH3:19][C:20]([S@:23]([NH:25][CH:14]([C:11]1[CH:12]=[N:13][C:8]([O:7][CH2:6][CH2:5][O:4][CH2:3][C:2]([F:18])([F:17])[F:1])=[CH:9][CH:10]=1)[CH3:15])=[O:24])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 67509694HCID 67509694, compound

Product 1

HCID 67511066HCID 67511066, compoundYield 24%

Procedure

The title compound is prepared in 24% yield (0.33 g, yellow oil) from 1-(6-(2-(2,2,2-trifluoroethoxy)ethoxy)pyridin-3-yl)ethanone (1.0 g, 3.80 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-9e6d07d6574446e5b25eafa5c0e8fada
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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