tert-Butylsulfinamide, (R)-(+)- → HCID 87426471, compound

HRID 623474Notes

Reaction equation

HRID 623474 reaction equation
[F:1][CH:2]([F:14])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([C:11](=O)[CH3:12])=[CH:7][CH:6]=1.[CH3:15][C:16]([S@:19]([NH2:21])=[O:20])([CH3:18])[CH3:17]>>[F:1][CH:2]([F:14])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([NH:21][S@@:19]([C:16]([CH3:18])([CH3:17])[CH3:15])=[O:20])[CH3:12])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 82006899HCID 82006899, compound

Product 1

HCID 87426471HCID 87426471, compoundYield 81%

Procedure

The title compound is prepared in 81% yield (1.24 g, colorless oil) from 1-(6-(2,2-difluoroethoxy)pyridin-3-yl)ethanone (1.0 g, 4.97 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-e2139b91e5004e6e99234b1de585818a
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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