HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoethane → Methyl 6-chloro-5-ethoxynicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Methyl 6-chloro-5-hydroxynicotinate | HCID 46941479 | — |
| Product | Methyl 6-chloro-5-ethoxynicotinate | HCID 87426133 | 43% |
Reaction Steps
The title compound is prepared in 43% yield (0.68 g, a white solid) from methyl 6-chloro-5-hydroxynicotinate (1.37 g, 7.28 mmol) and iodoethane instead of iodomethane by the similar manner in Step-2 of Amine-4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-21118288522543c79e11ceadb98f768d |
| Source note | uspto-grants-2016_04 |