tert-Butylsulfinamide, (R)-(+)- → HCID 67509076, compound

HRID 623483Notes

Reaction equation

HRID 623483 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:16](=O)[CH3:17])[CH:7]=[N:8][C:9]=1[O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH3:2].[CH3:19][C:20]([S@:23]([NH2:25])=[O:24])([CH3:22])[CH3:21]>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:16]([NH:25][S@@:23]([C:20]([CH3:22])([CH3:21])[CH3:19])=[O:24])[CH3:17])[CH:7]=[N:8][C:9]=1[O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH3:2]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 67508856HCID 67508856, compound

Product 1

HCID 67509076HCID 67509076, compoundYield 93%

Procedure

The title compound is prepared in 93% yield (0.75 g, colorless oil) from 1-(5-ethoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanone (0.58 g, 2.19 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-b30e5984cc3a41a99c6cd1262c349967
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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