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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623485Generated: October 26, 2026

6-Chloro-3-pyridinecarbonitrile → (R)-6-((1,1,1-trifluoropropan-2-yl)oxy)nicotinonitrile

https://huagongshe.com/reaction/623485

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Chloro-3-pyridinecarbonitrileHCID 5152094—
Reactant(2R)-1,1,1-trifluoropropan-2-olHCID 6993809—
Product(R)-6-((1,1,1-trifluoropropan-2-yl)oxy)nicotinonitrileHCID 6750931076%

Reaction Steps

The title compound is prepared in 76% yield (592 mg, colorless oil) from 6-chloronicotinonitrile (500 mg, 3.61 mmol) and (R)-1,1,1-trifluoropropan-2-ol instead of 2,2,2-trifluoroethanol by the similar manner in Step-1 of Amine-1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302991B2
Source datasetuspto-grants-2016_04
ORD IDord-bac21d070dbc47f9bdca0f0779cccc1d
Source noteuspto-grants-2016_04