tert-Butylsulfinamide, (R)-(+)- → HCID 67509504, compound

HRID 623491Notes

Reaction equation

HRID 623491 reaction equation
C([O:4][CH2:5][C:6]1[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[N:8][CH:9]=[C:10]([C:12](=O)[CH3:13])[CH:11]=1)(=O)C.[CH3:21][C:22]([S@:25]([NH2:27])=[O:26])([CH3:24])[CH3:23]>>[OH:4][CH2:5][C:6]1[CH:11]=[C:10]([CH:12]([NH:27][S@@:25]([C:22]([CH3:24])([CH3:23])[CH3:21])=[O:26])[CH3:13])[CH:9]=[N:8][C:7]=1[O:15][CH2:16][C:17]([F:18])([F:19])[F:20]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 67509523HCID 67509523, compound

Product 1

HCID 67509504HCID 67509504, compoundYield 57%

Procedure

The title compound is prepared in 57% yield (0.11 g, colorless oil) from (5-acetyl-2-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl acetate (0.16 g, 0.55 mmol, Step-7) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-dd7cee71f2c64b00bfb959cb1478bf32
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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