2,2-Difluoroethan-1-ol → HCID 75480831, compound

HRID 623494Notes

Reaction equation

HRID 623494 reaction equation
[Cl:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:12][CH:13]([F:16])[CH2:14][OH:15]>>[Cl:1][C:2]1[C:3]([O:15][CH2:14][CH:13]([F:16])[F:12])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 1361872,2-Difluoroethan-1-olHCID 2479875,6-Dichloronicotinic acid

Product 1

HCID 75480831HCID 75480831, compoundYield 83%

Procedure

The title compound is prepared in 83% yield (4.12 g, a white solid) from 5,6-dichloronicotinic acid (4.00 g, 20.8 mmol) and 2,2-difluoroethanol instead of 2,2,2-trifluoroethanol by the similar manner in Step-1 of Amine-1.

Sources & evidence

ORD record
ord-52e1184c159641f09cfe2e58939a017b
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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