tert-Butylsulfinamide, (R)-(+)- → HCID 87426539, compound

HRID 623502Notes

Reaction equation

HRID 623502 reaction equation
[F:1][C:2]([F:18])([C:14]([F:17])([F:16])[F:15])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([C:11](=O)[CH3:12])=[CH:7][CH:6]=1.[CH3:19][C:20]([S@:23]([NH2:25])=[O:24])([CH3:22])[CH3:21]>>[CH3:19][C:20]([S@:23]([NH:25][CH:11]([C:8]1[CH:9]=[N:10][C:5]([O:4][CH2:3][C:2]([F:18])([F:1])[C:14]([F:17])([F:16])[F:15])=[CH:6][CH:7]=1)[CH3:12])=[O:24])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87426288HCID 87426288, compound

Product 1

HCID 87426539HCID 87426539, compoundYield 78%

Procedure

The title compound is prepared in 78% yield (3.2 g, an off-white solid) from 1-(6-(2,2,3,3,3-pentafluoropropoxy)pyridin-3-yl)ethanone (3.0 g, 11.0 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-ca2173baf9ef4e09a0d9183de80d5548
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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