HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-bromo-6-(2,2,2-trifluoroethoxy)nicotinate → Methyl 5-ethyl-6-(2,2,2-trifluoroethoxy)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-bromo-6-(2,2,2-trifluoroethoxy)nicotinate | HCID 66686828 | — |
| Reactant | HCID 178418750 | HCID 178418750 | — |
| Product | Methyl 5-ethyl-6-(2,2,2-trifluoroethoxy)nicotinate | HCID 67510225 | 73% |
Reaction Steps
The title compound is prepared in 73% yield (610 mg, a white solid) from methyl 5-bromo-6-(2,2,2-trifluoroethoxy)nicotinate (1.0 g, 3.2 mmol, Step-1) and diethylzinc (6.4 mL, 6.4 mmol, 1M solution in n-hexane) instead of dimethylzinc by the similar manner in Step-3 of Amine-27.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-3c98c2ce92a1408b9ce8eff33afa6f27 |
| Source note | uspto-grants-2016_04 |