HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloronicotinic acid → 6-(2,2-Difluoropropoxy)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Reactant | 2,2-Difluoropropanol | HCID 13394818 | — |
| Product | 6-(2,2-Difluoropropoxy)nicotinic acid | HCID 67509293 | 99% |
Reaction Steps
The title compound is prepared in >99% yield (1.79 g, orange oil) from 6-chloronicotinic acid (1.3 g, 8.25 mmol) and 2,2-difluoropropan-1-ol instead of 2,2,2-trifluoroethanol by the similar manner in Step-1 of Amine-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-e8f4b28097124330b8f435e0bac882e3 |
| Source note | uspto-grants-2016_04 |