2,2-Difluoroethan-1-ol → HCID 87426511, compound

HRID 623511Notes

Reaction equation

HRID 623511 reaction equation
F[C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[F:12][CH:13]([F:16])[CH2:14][OH:15]>>[F:12][CH:13]([F:16])[CH2:14][O:15][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 1361872,2-Difluoroethan-1-olHCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acid

Product 1

HCID 87426511HCID 87426511, compoundYield 87%

Procedure

The title compound is prepared in 87% yield (849 mg, a pale yellow solid) from 6-fluoro-4-methylnicotinic acid (700 mg, 4.51 mmol) and 2,2-difluoroethanol (555 mg, 6.77 mmol) instead of 2,2,2-trifluoroethanol by the similar manner in Step-1 of Amine-1.

Sources & evidence

ORD record
ord-a32f4c110a7a493986f1cfcc9721739f
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

Loading…