tert-Butylsulfinamide, (R)-(+)- → HCID 67509758, compound

HRID 623513Notes

Reaction equation

HRID 623513 reaction equation
[F:1][C:2]([F:15])([CH3:14])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([C:11](=O)[CH3:12])=[CH:7][CH:6]=1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[F:1][C:2]([F:15])([CH3:14])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([NH:22][S@@:20]([C:17]([CH3:19])([CH3:18])[CH3:16])=[O:21])[CH3:12])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 67510600HCID 67510600, compound

Product 1

HCID 67509758HCID 67509758, compoundYield 85%

Procedure

The title compound is prepared in 85% yield (0.95 g, colorless oil) from 1-(6-(2,2-difluoropropoxy)pyridin-3-yl)ethanone (0.75 g, 3.49 mmol, Step-2) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-4162bc4569eb4845a4c7a0b27dc19a6b
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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