tert-Butylsulfinamide, (R)-(+)- → HCID 87426989, compound

HRID 623517Notes

Reaction equation

HRID 623517 reaction equation
[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([C:11](=O)[CH3:12])=[CH:7][C:6]=1[CH2:14][CH3:15].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([NH:23][S@@:21]([C:18]([CH3:20])([CH3:19])[CH3:17])=[O:22])[CH3:12])=[CH:7][C:6]=1[CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87426778HCID 87426778, compound

Product 1

HCID 87426989HCID 87426989, compoundYield 76%

Procedure

The title compound is prepared in 76% yield (240 mg, clear colorless oil) from 1-(6-(2,2-difluoroethoxy)-5-ethylpyridin-3-yl)ethanone (220 mg, 0.94 mmol, Step-6) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-de3747d996e34aeda6ea2ee6303c3df0
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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