HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,3,3-Tetrafluoro-1-propanol → 5-Methyl-6-(2,2,3,3-tetrafluoropropoxy)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,3,3-Tetrafluoro-1-propanol | HCID 6441 | — |
| Reactant | 6-Fluoro-5-methylpyridine-3-carboxylic acid | HCID 16414223 | — |
| Product | 5-Methyl-6-(2,2,3,3-tetrafluoropropoxy)nicotinic acid | HCID 87426383 | 99% |
Reaction Steps
The title compound is prepared in >99% yield (3.7 g, a white solid) from 6-fluoro-5-methylnicotinic acid (2.0 g, 12.9 mmol) and 2,2,3,3-tetrafluoropropan-1-ol (3.4 g, 25.8 mmol) instead of 2,2,2-trifluoroethanol by the similar manner in Step-1 of Amine-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-626decb9c09142b699dd288118625846 |
| Source note | uspto-grants-2016_04 |