tert-Butylsulfinamide, (R)-(+)- → HCID 87426922, compound

HRID 623521Notes

Reaction equation

HRID 623521 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6]([C:15](=O)[CH3:16])[CH:7]=[N:8][C:9]=2[O:10][CH2:11][CH:12]([F:14])[F:13])[CH2:3][CH2:2]1.[CH3:18][C:19]([S@:22]([NH2:24])=[O:23])([CH3:21])[CH3:20]>>[CH:1]1([C:4]2[CH:5]=[C:6]([CH:15]([NH:24][S@@:22]([C:19]([CH3:21])([CH3:20])[CH3:18])=[O:23])[CH3:16])[CH:7]=[N:8][C:9]=2[O:10][CH2:11][CH:12]([F:14])[F:13])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87426724HCID 87426724, compound

Product 1

HCID 87426922HCID 87426922, compoundYield 73%

Procedure

The title compound is prepared in 73% yield (0.21 g, colorless oil) from 1-(5-cyclopropyl-6-(2,2-difluoroethoxy)pyridin-3-yl)ethanone (0.20 g, 0.82 mmol, Step-3) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-6009703e03e14801b190143e67f24f98
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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