tert-Butylsulfinamide, (R)-(+)- → HCID 87426486, compound

HRID 623524Notes

Reaction equation

HRID 623524 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:13](=O)[CH3:14])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH:10]([F:12])[F:11].[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]([NH:22][S@@:20]([C:17]([CH3:19])([CH3:18])[CH3:16])=[O:21])[CH3:14])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH:10]([F:12])[F:11]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 82007385HCID 82007385, compound

Product 1

HCID 87426486HCID 87426486, compoundYield 62%

Procedure

The title compound is prepared in 62% yield (780 mg, clear colorless oil) from 1-(3-chloro-4-(2,2-difluoroethoxy)phenyl)ethanone (860 mg, 3.7 mmol, Step-2) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-d98ac0e9c4bd4b688b36db9d73cec100
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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