tert-Butylsulfinamide, (R)-(+)- → HCID 87426405, compound

HRID 623525Notes

Reaction equation

HRID 623525 reaction equation
[F:1][CH:2]([F:15])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=O)[CH3:12])=[C:7]([CH3:14])[CH:6]=1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[F:1][CH:2]([F:15])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([NH:22][S@@:20]([C:17]([CH3:19])([CH3:18])[CH3:16])=[O:21])[CH3:12])=[C:7]([CH3:14])[CH:6]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87426462HCID 87426462, compound

Product 1

HCID 87426405HCID 87426405, compoundYield 42%

Procedure

The title compound is prepared in 42% yield (1.0 g, clear colorless oil) from 1-(4-(2,2-difluoroethoxy)-2-methylphenyl)ethanone (1.6 g, 7.5 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-aaa3c94f01424d9b823be6fbbb273824
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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