tert-Butylsulfinamide, (R)-(+)- → HCID 87426999, compound

HRID 623532Notes

Reaction equation

HRID 623532 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH:10]([F:12])[F:11])[CH:5]=[CH:4][C:3]=1[C:13](=O)[CH3:14].[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH:10]([F:12])[F:11])[CH:5]=[CH:4][C:3]=1[CH:13]([NH:22][S@@:20]([C:17]([CH3:19])([CH3:18])[CH3:16])=[O:21])[CH3:14]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 82006900HCID 82006900, compound

Product 1

HCID 87426999HCID 87426999, compoundYield 55%

Procedure

The title compound is prepared in 55% yield (990 mg, clear colorless oil) from 1-(2-chloro-4-(2,2-difluoroethoxy)phenyl)ethanone (1.2 g, 5.2 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-f08b728931ae4d41b3736b0a05b0be08
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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