tert-Butylsulfinamide, (R)-(+)- → HCID 87426306, compound

HRID 623533Notes

Reaction equation

HRID 623533 reaction equation
[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[C:10]([F:11])=[CH:9][C:8]([C:12](=O)[CH3:13])=[CH:7][C:6]=1[F:15].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[C:10]([F:11])=[CH:9][C:8]([CH:12]([NH:23][S@@:21]([C:18]([CH3:20])([CH3:19])[CH3:17])=[O:22])[CH3:13])=[CH:7][C:6]=1[F:15]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87427044HCID 87427044, compound

Product 1

HCID 87426306HCID 87426306, compoundYield 88%

Procedure

The title compound is prepared in 88% yield (750 mg, a white solid) from 1-(4-(2,2-difluoroethoxy)-3,5-difluorophenyl)ethanone (590 mg, 2.5 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-23cbe4e2a5174aa997c2d6042c5e7499
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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