tert-Butylsulfinamide, (R)-(+)- → HCID 87426245, compound

HRID 623536Notes

Reaction equation

HRID 623536 reaction equation
[F:1][CH:2]([F:15])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:14])=[C:9]([C:11](=O)[CH3:12])[CH:10]=1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[F:1][CH:2]([F:15])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:14])=[C:9]([CH:11]([NH:22][S@@:20]([C:17]([CH3:19])([CH3:18])[CH3:16])=[O:21])[CH3:12])[CH:10]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87426733HCID 87426733, compound

Product 1

HCID 87426245HCID 87426245, compoundYield 61%

Procedure

The title compound is prepared in 61% yield (400 mg, clear colorless oil) from 1-(5-(2,2-difluoroethoxy)-2-methylphenyl)ethanone (440 mg, 2.1 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-fbe2961df3e746e580c9732fbdcc53f1
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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