tert-Butylsulfinamide, (R)-(+)- → HCID 87426329, compound

HRID 623539Notes

Reaction equation

HRID 623539 reaction equation
[F:1][CH:2]([F:15])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:12](=O)[CH3:13])[CH:8]=[CH:9][C:10]=1[CH3:11].[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[F:1][CH:2]([F:15])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:12]([NH:22][S@@:20]([C:17]([CH3:19])([CH3:18])[CH3:16])=[O:21])[CH3:13])[CH:8]=[CH:9][C:10]=1[CH3:11]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87426358HCID 87426358, compound

Product 1

HCID 87426329HCID 87426329, compoundYield 66%

Procedure

The title compound is prepared in 66% yield (860 mg, clear colorless oil) from 1-(3-(2,2-difluoroethoxy)-4-methylphenyl)ethanone (880 mg, 4.1 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-3e11b7a390f7495d89594e392f4fc7ef
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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