2-Fluoro-4-(trifluoromethyl)benzaldehyde → HCID 87426482, compound

HRID 623540Notes

Reaction equation

HRID 623540 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH3:14][C:15]([S@@:18]([NH2:20])=[O:19])([CH3:17])[CH3:16]>>[F:1][C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1/[CH:4]=[N:20]/[S@:18]([C:15]([CH3:17])([CH3:16])[CH3:14])=[O:19]

Participants

3

Reactant 2

HCID 5229292-Fluoro-4-(trifluoromethyl)benzaldehydeHCID 11355477tert-Butylsulfinamide, (S)-(-)-

Product 1

HCID 87426482HCID 87426482, compoundYield 95%

Procedure

The title compound is prepared in 95% yield (1.17 g, a pale yellow solid) from 2-fluoro-4-(trifluoromethyl)benzaldehyde (800 mg, 4.16 mmol) and (S)-2-methylpropane-2-sulfinamide (606 mg, 5.00 mmol) by the similar manner in Step-1 of Amine-88.

Sources & evidence

ORD record
ord-3084575403d441f7844829b9a766ee2b
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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