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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623541Generated: October 30, 2026

6-Bromopyridine-3-carbonitrile → 6-(2-(Trifluoromethoxy)ethoxy)nicotinonitrile

https://huagongshe.com/reaction/623541

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromopyridine-3-carbonitrileHCID 5005718—
Reactant2-(Trifluoromethoxy)ethan-1-olHCID 17951687—
Product6-(2-(Trifluoromethoxy)ethoxy)nicotinonitrileHCID 6751070995%

Reaction Steps

The title compound is prepared in 95% yield (509 mg, colorless oil) from 6-bromonicotinonitrile (422 mg, 2.31 mmol) and 2-(trifluoromethoxy)ethanol (300 mg, 2.31 mmol) by the similar manner in Step-1 of Amine-101.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302991B2
Source datasetuspto-grants-2016_04
ORD IDord-f77dfa4bbe0043d3a105b95e9fc27b47
Source noteuspto-grants-2016_04