tert-Butylsulfinamide, (R)-(+)- → HCID 87426153, compound

HRID 623543Notes

Reaction equation

HRID 623543 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:14](=O)[CH3:15])[CH:5]=[C:6]([CH3:13])[C:7]=1[O:8][CH2:9][CH:10]([F:12])[F:11].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]([NH:23][S@@:21]([C:18]([CH3:20])([CH3:19])[CH3:17])=[O:22])[CH3:15])[CH:5]=[C:6]([CH3:13])[C:7]=1[O:8][CH2:9][CH:10]([F:12])[F:11]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87426181HCID 87426181, compound

Product 1

HCID 87426153HCID 87426153, compoundYield 93%

Procedure

The title compound is prepared in 93% yield (0.85 g, yellow oil) from 1-(3-chloro-4-(2,2-difluoroethoxy)-5-methylphenyl)ethanone (0.65 g, 2.61 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-0d0729b7955e473097f1fa1d920e28cf
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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