tert-Butylsulfinamide, (R)-(+)- → HCID 87426575, compound

HRID 623544Notes

Reaction equation

HRID 623544 reaction equation
[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([C:12](=O)[CH3:13])=[CH:7][C:6]=1[CH3:15].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([CH:12]([NH:23][S@@:21]([C:18]([CH3:20])([CH3:19])[CH3:17])=[O:22])[CH3:13])=[CH:7][C:6]=1[CH3:15]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 87426403HCID 87426403, compound

Product 1

HCID 87426575HCID 87426575, compoundYield 89%

Procedure

The title compound is prepared in 89% yield (0.89 g, yellow oil) from 1-(4-(2,2-difluoroethoxy)-3,5-dimethylphenyl)ethanone (0.68 g, 2.98 mmol, Step-1) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

Sources & evidence

ORD record
ord-670197b3f8f54a80aa36e95f39be076f
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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